Using Cron Control you'll be able to fine tune drupal's cron espacially in clustered environments.
Using current version of Cron Control you'll be able to turn on or off single cron jobs or define on which server they should run.
For example transcoding videos should not decrease your site's performance. Using Cron Control you're able to configure each server in a clustered environment to do that job dedicated while others serve your pages.
Or outsource number crunching cron jobs like transcoding videos to a cloud which doesn't need to be available all the time. These cron jobs will run as soon as your number cruncher is available while your regular webservers keep runing "normal" cron jobs continuously.